Endocrine Abstracts

Background: Obesity is increasing in prevalence in younger people, including children and adolescents. Bariatric surgery (BS) is well-established and efficacious treatment for morbid obesity in adults. BS is being performed in younger age groups more frequently.Objective: To describe outcomes of BS under the age of 25 in Emirati individuals having follow-up at Imperial College London Diabetes Centre (ICLDC).Methods: Patients recrui...

Background: Cardiovascular disease (CVD) is a leading cause of mortality. Childhood obesity is a major contributor to CVD. Atherogenic index of plasma (AIP) is an indicator of risk of atherosclerotic CVD. Associations between childhood obesity and CVD risk in the region remains under-explored. We aim to investigate this association as a predictor of CVD in this young population.Methods: Patients who attended our Centre (2009-2019), age ≤19 years an...

Background: The obesity prevalence surge in children and adolescents is associated with dysglycaemia, dyslipidaemia and long-term cardiovascular complications. Use of lipid-lowering medications1 has been recommended following lifestyle modifications. We aim to investigate the demographic, and changes in LDL-c, in these young patients, in the presence and absence of dysglycaemia.Methods: Complete lipid profiles of patients (≤19 years old)...

Background and aims: We previously reported BMI heritability in the UAE to be 39.9%; indicating a high (60.1%) contribution of environmental factors to obesity. This study aims to determine and compare co-twin monozygotic (MZ) and dizygotic (DZ) BMI concordances.Materials and methods: 200 twin pairs were identified (ICLDC patient database) and split into two age groups (≤18 and >18 years old). Opposite gender twin sets were considered DZ. In same g...

Background: Ramadan fasting entails abstinence of food and drink from dawn to sunset for 30 days. Medication timing also changes; for patients with hypothyroidism this can be a challenge as levothyroxine (LT4) is normally taken on an empty stomach and at least half an hour before breakfast. Complying with this advice during Ramadan is impractical for religious and social reasons. Adverse changes in thyroid function in patients with hypothyroidism have been observed. Whether an...

Covid-19 infection severity has been associated with pre-existing conditions including obesity. Individuals with Down Syndrome (DS) are potentially at high risk. Reports on the outcomes of Covid-19 infection in individuals with DS are scant. Here we present such a case. MA is a 27-year old Emirati male with DS, obesity and hypothyroidism. He was brought to the ER with a history of hemoptysis (2 days), fever and cough (1 week). He tested positive for Covid-19. Initial investiga...

IntroductionMelanocortin-4-receptor (MC4R) deficiency is the commonest of the rare monogenic forms of obesity. Bariatric surgery (BS) is the most efficacious treatment modality in the more ’common’ polygenic obesity. Effect of surgical and drug treatment in obesity due to MC4R deficiency is not well-established.AimWe aimed to explore the effects of BS and drug treatment among the confirmed cases of ...